APOTEK DI DASAR SAMUDRA: BAGAIMANA BIOTEKNOLOGI MENGUBAH RACUN HEWAN LAUT MENJADI OBAT KANKER

Marsyahip

doi:10.55681/aohj.v2i3.513

Authors

Marsyahip Politeknik Sains Gelobal

DOI:

https://doi.org/10.55681/aohj.v2i3.513

Keywords:

Ocean pharmacy, Biotecnology, Cancer Drugs

Abstract

The reviewed article discusses the extraordinary potential of the ocean as a source for the discovery of new drugs (marine natural products), with a specific focus on the utilization of toxins (biotoxins) produced by marine animals to be developed into anticancer agents. Through the integration of marine biology, molecular biotechnology, and pharmacology, lethal toxins from organisms such as cone snails (Conus sp.), sea snakes, and jellyfish can be structurally deconstructed and engineered to selectively destroy tumor cells without harming healthy tissue. This review aims to analyze the biotechnological mechanisms in the isolation of biotoxins, their efficacy as cytostatics, and the challenges in commercializing marine-based pharmaceutical products.

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References

Aneiros, A., & Garateix, A. (2004). Bioactive peptides from marine sources: Pharmacological properties and isolation procedures. Journal of Chromatography B, 803(1), 41–53.

Calcul, L., Chow, R., & Baker, B. J. (2013). Marine natural products as leads for therapeutic agents. PharmaNutrition, 1(2), 40–50.

Dyshel, T., & Gurevitz, M. (2019). Recombinant expression and engineering of marine animal toxins for pharmacological applications. Toxins, 11(8), 450.

King, G. F. (2011). Venoms as a platform for the discovery of therapeutically relevant peptides and small molecules. Expert Opinion on Drug Discovery, 6(1), 29–40.

Newman, D. J., & Cragg, G. M. (2020). Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. Journal of Natural Products, 83(3), 770–803.